Genomic landscape of early-stage prostate adenocarcinoma in Mexican patients: an exploratory study.

ABSTRACT:

Background

Health disparities have been highlighted among patient with prostate adenocarcinoma (PRAD) due to ethnicity. Mexican men present a more aggressive disease than other patients resulting in less favorable treatment outcome. We aimed to identify the mutational landscape which could help to reduce the health disparities among minority groups and generate the first genomics exploratory study of PRAD in Mexican patients.

Methods

Paraffin-embedded formalin-fixed tumoral tissue from 20 Mexican patients with early-stage PRAD treated at The Instituto Nacional de Cancerología, Mexico City from 2017 to 2019 were analyzed. Tumoral DNA was prepared for whole exome sequencing, the resulting files were mapped against h19 using BWA-MEM. Strelka2 and Lancet packages were used to id

SUBMITTER: Cerrato-Izaguirre D 

PROVIDER: S-EPMC11358564 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature