Investigation of transcriptional and immunological disparities among patient groups with varied prognostic risk factors in cholangiocarcinoma.

ABSTRACT:

Background

This study explores molecular features associated with better prognosis in cholangiocarcinoma (CCA).

Methods and results

The transcriptomic and whole-exome sequencing data obtained from paired tissues of 70 were analyzed, grouping them based on progression-free survival (PFS), differentiation degree, and lymph node metastasis. Among the 70 patients, the TP53 gene mutation frequency was the highest (53%), while FLG gene mutation occurred exclusively in the long PFS group. In the comparison between long and short survival groups, the short PFS group exhibited higher monocyte infiltration levels (p = 0.0287) and upregulation of genes associated with cancer-related transcriptional misregulation, chemokine signaling, and cytokine-cytokine receptor interactions. Differe

SUBMITTER: Zhang B 

PROVIDER: S-EPMC11358702 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature