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Durable benefit and slowdown in tumor growth dynamics with erdafitinib in a FGFR3-TACC3 fusion-positive IDH-wild type glioblastoma.

ABSTRACT: FGFR3-TACC3 fusion-positive IDH-wild-type (IDH-WT) glioblastoma (GB) is a rare GB subtype occurring in approximately 3% of cases. It is clinical behavior and molecular profile is different from those of fusion-negative IDH-WT GBs. Evidence on the role of FGFR inhibitors in FGFR-altered gliomas is limited. We present the case of a patient with a FGFR3-TACC3 fusion-positive IDH-WT GB that at its second recurrence was treated with the FGFR inhibitor erdafitinib through a compassionate use program. Although no objective response was achieved, an overt deceleration in tumor growth was evidenced and the patient remained on treatment for 5.5 months.

SUBMITTER: Cabezas-Camarero S

PROVIDER: S-EPMC11358818 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature

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Durable benefit and slowdown in tumor growth dynamics with erdafitinib in a FGFR3-TACC3 fusion-positive IDH-wild type glioblastoma.

Cabezas-Camarero Santiago S Pérez-Alfayate Rebeca R Polidura Carmen C Gómez-Ruiz María Natividad MN Gil-Martínez Lidia L Casado-Fariñas Isabel I Bartolomé Jorge J Pérez-Segura Pedro P

Neuro-oncology advances 20240101 1

FGFR3-TACC3 fusion-positive IDH-wild-type (IDH-WT) glioblastoma (GB) is a rare GB subtype occurring in approximately 3% of cases. It is clinical behavior and molecular profile is different from those of fusion-negative IDH-WT GBs. Evidence on the role of FGFR inhibitors in FGFR-altered gliomas is limited. We present the case of a patient with a FGFR3-TACC3 fusion-positive IDH-WT GB that at its second recurrence was treated with the FGFR inhibitor erdafitinib through a compassionate use program. ...[more]

PMID: 39211518

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Extra-CNS and dural metastases in FGFR3::TACC3 fusion+ adult glioblastoma, IDH-wildtype.

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The tumorigenic fusion FGFR3-TACC3 escapes miR-99a regulation in glioblastoma

Project description:This SuperSeries is composed of the SubSeries listed below.

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The tumorigenic fusion FGFR3-TACC3 escapes miR-99a regulation in glioblastoma

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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