First-Generation Antihistamines and Seizures in Young Children.

ABSTRACT:

Importance

The widespread use of antihistamines in children for treatment of common cold symptoms and their central nervous system effects, like drowsiness, underscore the importance of being aware of the associated risks.

Objective

To assess associations between prescriptions of first-generation antihistamines and seizures in children using a comprehensive and nationwide dataset.

Design, setting, and participants

This cohort study used a self-controlled case-crossover design. Data were obtained from the National Health Insurance Service database in Korea. Children born between January 1, 2002, and December 31, 2005, who visited the emergency department for seizure events (International Statistical Classification of Diseases and Related Health Problems, Tenth Revision

SUBMITTER: Kim JH 

PROVIDER: S-EPMC11358850 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature