Dataset Information

Consumption of Total and Specific Alcoholic Beverages and Long-Term Risk of Gout Among Men and Women.

ABSTRACT:

Importance

Previous studies on alcohol consumption and incident gout have mostly included men or combined both sexes, and the sex-specific associations between alcohol consumption and gout are poorly understood.

Objective

To evaluate the consumption of total and specific alcoholic beverages in association with incident gout in men and women.

Design, setting, and participants

This prospective cohort study included 401 128 participants in the UK Biobank aged 37 to 73 years who were free of gout at baseline (2006-2010). Participants were followed up through December 31, 2021, and data were analyzed between August 2023 and June 2024.

Exposure

Questionnaire-based consumption of total alcohol and specific alcoholic beverages.

Main outcomes and measures

The outcome was incident gout, identified using hospital records. Multivariable Cox proportional hazards regression models were used to estimate sex-specific hazard ratios (HRs) and 95% CIs of incident gout associated with alcohol consumption, with a particular consideration of reverse causation bias.

Results

The main analysis included 179 828 men (mean [SD] age, 56.0 [8.2] years) and 221 300 women (mean [SD] age, 56.0 [8.0] years). Current drinkers showed a higher risk of gout than never drinkers among men (HR, 1.69; 95% CI, 1.30-2.18) but not among women (HR, 0.83; 95% CI, 0.67-1.03). Among current drinkers, higher total alcohol consumption was associated with a higher risk of gout among both sexes and more strongly among men than women (men: HR, 2.05 [95% CI, 1.84-2.30]; women: HR, 1.34 [95% CI, 1.12-1.61]). The most evident sex difference in the consumption of specific alcoholic beverages was observed for beer or cider (men: mean [SD], 4.2 [4.8] pints per week; women: mean [SD], 0.4 [1.1] pints per week). Consumption of champagne or white wine, beer or cider, and spirits each was associated with a higher risk of gout among both sexes, with beer or cider showing the strongest association per 1 pint per day (men: HR, 1.60 [95% CI, 1.53-1.67]; women: HR, 1.62 [95% CI, 1.02-2.57]). Some inverse associations between light to moderate consumption of specific alcoholic beverages and gout were eliminated after adjusting for other alcoholic beverages and excluding individuals who had reduced alcohol consumption for health reasons, self-reported poor health, or had cardiovascular disease, cancer, or kidney failure at baseline, or developed gout within the first 2 years of follow-up.

Conclusions and relevance

In this cohort study, higher consumption of several specific alcoholic beverages was associated with a higher risk of gout among both sexes. The sex-specific associations for total alcohol consumption may be associated with differences between men and women in the types of alcohol consumed.

SUBMITTER: Lyu JQ

PROVIDER: S-EPMC11358860 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Consumption of Total and Specific Alcoholic Beverages and Long-Term Risk of Gout Among Men and Women.

Lyu Jie-Qiong JQ Miao Meng-Yuan MY Wang Jia-Min JM Qian Yu-Wen YW Han Wen-Wen WW Peng Xian-Zhen XZ Tao Hao-Wei HW Yang Jing J Chen Jing-Si JS Qin Li-Qiang LQ Chen Wei W Chen Guo-Chong GC

JAMA network open 20240801 8

<h4>Importance</h4>Previous studies on alcohol consumption and incident gout have mostly included men or combined both sexes, and the sex-specific associations between alcohol consumption and gout are poorly understood.<h4>Objective</h4>To evaluate the consumption of total and specific alcoholic beverages in association with incident gout in men and women.<h4>Design, setting, and participants</h4>This prospective cohort study included 401 128 participants in the UK Biobank aged 37 to 73 years wh ...[more]

PMID: 39196557

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Dataset Information

Consumption of Total and Specific Alcoholic Beverages and Long-Term Risk of Gout Among Men and Women.

Importance

Objective

Design, setting, and participants

Exposure

Main outcomes and measures

Results

Conclusions and relevance

Publications

Consumption of Total and Specific Alcoholic Beverages and Long-Term Risk of Gout Among Men and Women.

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