Sleep maintains excitatory synapse diversity in the cortex and hippocampus.

ABSTRACT: Insufficient sleep is a global problem with serious consequences for cognition and mental health.¹ Synapses play a central role in many aspects of cognition, including the crucial function of memory consolidation during sleep.² Interference with the normal expression or function of synapse proteins is a cause of cognitive, mood, and other behavioral problems in over 130 brain disorders.³ Sleep deprivation (SD) has also been reported to alter synapse protein composition and synapse number, although with conflicting results.^4,5,6,7 In our study, we conducted synaptome mapping of excitatory synapses in 125 regions of the mouse brain and found that sleep deprivation selectively reduces

SUBMITTER: Koukaroudi D 

PROVIDER: S-EPMC11359089 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature