Polygenic Risk Scores and Twin Concordance for Schizophrenia and Bipolar Disorder.

ABSTRACT:

Importance

Schizophrenia and bipolar disorder are highly heritable psychiatric disorders with strong genetic and phenotypic overlap. Twin and molecular methods can be leveraged to predict the shared genetic liability to these disorders.

Objective

To investigate whether twin concordance for psychosis depends on the level of polygenic risk score (PRS) for psychosis and zygosity and compare PRS from cases and controls from several large samples and estimate the twin heritability of psychosis.

Design, setting, and participants

In this case-control study, psychosis PRS were generated from a genome-wide association study (GWAS) combining schizophrenia and bipolar disorder into a single psychosis phenotype and compared between cases and controls from the Schizophrenia and Bi

SUBMITTER: Song J 

PROVIDER: S-EPMC11359115 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature