Distrust in the Health Care System and Adherence to Direct-Acting Antiviral Therapy among People with Hepatitis <i>C Virus</i> Who Inject Drugs.

ABSTRACT: This study is a secondary analysis of a randomized clinical trial (October 2013-April 2017) involving 150 People Who Inject Drugs (PWIDs) with hepatitis C virus (HCV) seen in opioid agonist treatment programs in the Bronx, New York, and investigates the impact of distrust in the healthcare system on adherence to Direct-Acting Antivirals (DAAs) HCV treatment therapy among PWIDs. The distrust was scaled on a 9-item instrument and the adherence to DAA medications was measured using electronic blister packs. This study demonstrated a significant inverse relationship between levels of distrust and medication adherence: 71.8 ± 2.2% (se) vs. 77.9 ± 1.8%, p = 0.024 between participants with higher and lower distrust levels. Despite the absence of significant association of distrust w

SUBMITTER: Padi A 

PROVIDER: S-EPMC11359142 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature