Characterization of the Anti-Viral and Vaccine-Specific CD8⁺ T Cell Composition upon Treatment with the Cancer Vaccine VSV-GP.

ABSTRACT: Numerous factors influence the magnitude and effector phenotype of vaccine-induced CD8⁺ T cells, thereby potentially impacting treatment efficacy. Here, we investigate the effect of vaccination dose, route of immunization, presence of a target antigen-expressing tumor, and heterologous prime-boost with peptide vaccine partner following vaccination with antigen-armed VSV-GP. Our results indicate that a higher vaccine dose increases antigen-specific CD8⁺ T cell proportions while altering the phenotype. The intravenous route induces the highest proportion of antigen-specific CD8⁺ T cells together with the lowest anti-viral response followed by the intraperitoneal, intramuscular, and subcutaneous routes. Moreover, the presence of a B16-OVA tumor serves as pre-p

SUBMITTER: Hofer T 

PROVIDER: S-EPMC11359161 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature