Electrospraying as a Means of Loading Itraconazole into Mesoporous Silica for Enhanced Dissolution.

ABSTRACT: Mesoporous silica particles (MSPs) have been investigated as potential carriers to increase the apparent solubility and dissolution rate of poorly water-soluble drugs by physically stabilising the amorphous nature of the loaded drug. In preparing such systems, it is recognized that the loading method has a critical impact on the physical state and performance of the drug. To date, there has been very limited investigation into the use of electrospraying for loading drugs into mesoporous silica. In this study, we further explore the use of this approach, in particular as a means of producing amorphous and high drug-loaded MSPs; the study includes an investigation of the effect of drug loading and MSP concentration on the formulation performance and process. A comparison with rotary evaporat

SUBMITTER: Volitaki C 

PROVIDER: S-EPMC11359385 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature