Effectiveness of colorectal cancer screening integrating non-genetic and genetic risk: a prospective study based on UK Biobank data.

ABSTRACT:

Objective

Few studies have evaluated the benefits of colorectal cancer (CRC) screening integrating both non-genetic and genetic risk factors. Here, we aimed to integrate an existing non-genetic risk model (QCancer-10) and a 139-variant polygenic risk score to evaluate the effectiveness of screening on CRC incidence and mortality.

Methods

We applied the integrated model to calculate 10-year CRC risk for 430,908 participants in the UK Biobank, and divided the participants into low-, intermediate-, and high-risk groups. We calculated the screening-associated hazard ratios (HRs) and absolute risk reductions (ARRs) for CRC incidence and mortality according to risk stratification.

Results

During a median follow-up of 11.03 years and 12.60 years, we observed 5,158 CRC cases

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11359493 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature