The Altered Neonatal CD8⁺ T Cell Immunodominance Hierarchy during Influenza Virus Infection Impacts Peptide Vaccination.

ABSTRACT: Neonates are more susceptible to influenza virus infection than adults, resulting in increased morbidity and mortality and delayed clearance of the virus. Generating effective CD8⁺ T cell responses may be important for improving vaccination outcomes in vulnerable populations, but neonatal T cells frequently respond differently than adult cells. We sought to understand CD8⁺ T cell specificity and immunodominance during neonatal influenza infection and how any differences from the adult hierarchy might impact peptide vaccine effectiveness. Neonatal C57BL/6 mice displayed an altered CD8⁺ T cell immunodominance hierarchy during influenza infection, preferentially responding to an epitope in the influenza protein PA rather than the co-dominant adult response to

SUBMITTER: Heil L 

PROVIDER: S-EPMC11359775 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature