Genomic Characterization of Three Canadian Mumps Outbreaks Demonstrates Endemic Transmission in Canada.

ABSTRACT: Despite the provision of a mumps vaccination program in Canada for over three decades, mumps has not reached elimination. Instead, a re-emergence has been observed in vaccinated populations, particularly in young adults. These outbreaks have been almost exclusively due to genotype G infections, a trend that has been seen in other countries with high mumps vaccination rates. To characterize mumps outbreaks in Canada, genomes from samples from Manitoba (n = 209), Newfoundland (n = 25), and Nova Scotia (n = 48) were sequenced and analysed by Bayesian inference. Whole genome sequencing was shown to be highly discriminatory for outbreak investigations compared to traditional Sanger sequencing. The results showed that mumps virus genotype G most likely circulated endemically

SUBMITTER: Frost JR 

PROVIDER: S-EPMC11359846 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature