Optimization of a Modular Nanotransporter Design for Targeted Intracellular Delivery of Photosensitizer.

ABSTRACT: Modular nanotransporters (MNTs) are drug delivery systems for targeted cancer treatment. As MNTs are composed of several modules, they offer the advantage of high specificity and biocompatibility in delivering drugs to the target compartment of cancer cells. The large carrier module brings together functioning MNT modules and serves as a platform for drug attachment. The development of smaller-sized MNTs via truncation of the carrier module appears advantageous in facilitating tissue penetration. In this study, two new MNTs with a truncated carrier module containing either an N-terminal (MNT_N) or a C-terminal (MNT_C) part were developed by genetic engineering. Both new MNTs demonstrated a high affinity for target receptors, as revealed by fluorescent-labeled ligand-com

SUBMITTER: Alieva RT 

PROVIDER: S-EPMC11360004 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature