Synthetic Naphthoquinone Inhibits Herpes Simplex Virus Type-1 Replication Targeting Na⁺, K⁺ ATPase.

ABSTRACT: Since 1970 acyclovir (ACV) has been the reference drug in treating herpes simplex virus (HSV) infections. However, resistant herpes simplex virus type 1 (HSV-1) strains have emerged, narrowing the treatment efficacy. The antiviral activity of classical Na⁺, K⁺ ATPase enzyme (NKA) inhibitors linked the viral replication to the NKA's activity. Herein, we evaluated the anti-HSV-1 activity of synthetic naphthoquinones, correlating their antiviral activity with NKA inhibition. We tested seven synthetic naphthoquinones initially at 50 μM on HSV-1-infected African green monkey kidney cells (VERO cells). Only one compound, 2-hydroxy-3-(2-thienyl)-1,4-naphthoquinone (AN-06), exhibited higher antiviral activity with a low cytotoxicity. AN-06 reduced the viral titer of 9 (log10)

SUBMITTER: Souza KFCSE 

PROVIDER: S-EPMC11360054 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature