Systemic inflammation following traumatic injury and its impact on neuroinflammatory gene expression in the rodent brain.

ABSTRACT:

Background

Trauma can result in systemic inflammation that leads to organ dysfunction, but the impact on the brain, particularly following extracranial insults, has been largely overlooked.

Methods

Building upon our prior findings, we aimed to understand the impact of systemic inflammation on neuroinflammatory gene transcripts in eight brain regions in rats exposed to (1) blast overpressure exposure [BOP], (2) cutaneous thermal injury [BU], (3) complex extremity injury, 3 hours (h) of tourniquet-induced ischemia, and hind limb amputation [CEI+tI+HLA], (4) BOP+BU or (5) BOP+CEI and delayed HLA [BOP+CEI+dHLA] at 6, 24, and 168 h post-injury (hpi).

Results

Globally, the number and magnitude of differentially expressed genes (DEGs) correlated with injury severity, systemi

SUBMITTER: Rowe CJ 

PROVIDER: S-EPMC11360339 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature