Amorphous Solid Dispersions: Implication of Method of Preparation and Physicochemical Properties of API and Excipients.

ABSTRACT: The present study investigated the effect of different polymers and manufacturing methods (hot melt extrusion, HME, and spray drying, SD) on the solid state, stability and pharmaceutical performance of amorphous solid dispersions. In the present manuscript, a combination of different binary amorphous solid dispersions containing 20% and 30% of drug loadings were prepared using SD and HME. The developed solid-state properties of the dispersions were evaluated using small- and wide-angle X-ray scattering (WAXS) and modulated differential scanning calorimetry (mDSC). The molecular interaction between the active pharmaceutical ingredients (APIs) and polymers were investigated via infrared (IR) and Raman spectroscopy. The in vitro release profile of the solid dispersions was also evaluated to c

SUBMITTER: Kushwah V 

PROVIDER: S-EPMC11360349 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature