The fate of inhaled uranium-containing particles upon clearance to gastrointestinal tract.

ABSTRACT: Uranium-bearing respirable dust can cause various health problems, such as cardiovascular and neurological disorders, cancers, immunosuppression, and autoimmunity. Exposure to elevated levels of uranium is linked to many such health conditions in Navajo Nation residents in northwestern New Mexico. Most studies have focused on the fate of inhaled dust particles (<4 μm) in the lungs. However, larger-sized inhaled particles (10-20 μm) can be cleared to the human gastrointestinal tract (GIT), thereby enabling them to interact with stomach and intestinal fluids. Despite the vital importance of understanding the fate of uranium-bearing solids entering the human GIT and their impact on body tissues, cells, and gut microbiota, our understanding remains limited. This study investigated uranium solu

SUBMITTER: Hettiarachchi E 

PROVIDER: S-EPMC11360387 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature