Elevated expression of Aurora-A/AURKA in breast cancer associates with younger age and aggressive features.

ABSTRACT:

Background and objective

Aurora kinase A (AURKA) is reported to be overexpressed in breast cancer. In addition to its role in regulating cell cycle and mitosis, studies have reported AURKA involvements in oncogenic signaling in suppressing BRCA1 and BRCA2. We aimed to characterize AURKA protein and mRNA expression in a breast cancer cohort of the young, investigating its relation to clinico-pathologic features and survival, and exploring age-related AURKA-associated biological processes.

Methods

Aurora kinase A immunohistochemical staining was performed on tissue microarrays of primary tumors from an in-house breast cancer cohort (n = 355) with information on clinico-pathologic data, molecular markers, and long and complete follow-up. A subset of the in-house cohort (n = 127

SUBMITTER: Ingebriktsen LM 

PROVIDER: S-EPMC11360479 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature