Primary biliary cholangitis has causal effects on systemic rheumatic diseases: a Mendelian randomization study.

ABSTRACT:

Background

An association has been observed between primary biliary cholangitis (PBC) and systemic rheumatic diseases (SRDs) in observational studies, however the exact causal link remains unclear. We aimed to evaluate the causal effects of PBC on SRDs through Mendelian randomization (MR) analysis.

Methods

The genome-wide association study (GWAS) summary data were obtained from MRC IEU OpenGWAS and FinnGen databases. Independent genetic variants for PBC were selected as instrumental variables. Inverse variance weighted was used as the main approach to evaluate the causal effects of PBC on Sjögren syndrome (SS), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), systemic sclerosis (SSc), mixed connective tissue disease (MCTD) and polymyositis (PM). Horizontal plei

SUBMITTER: Zhang HP 

PROVIDER: S-EPMC11360496 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature