Comparison of Post-Vaccination Cellular Immune Response in Patients with Common Variable Immune Deficiency.

ABSTRACT:

Background

The problem of identifying vaccine-specific T-cell responses is still a matter of debate. Currently, there are no universal, clearly defined, agreed upon criteria for assessing the effectiveness of vaccinations and their immunogenicity for the cellular component of immunity, even for healthy people. But for patients with inborn errors of immunity (IEI), especially those with antibody deficiencies, evaluating cellular immunity holds significant importance.

Aim

To examine the effect of one and two doses of inactivated adjuvanted subunit influenza vaccines on the expression of endosomal Toll-like receptors (TLRs) on the immune cells and the primary lymphocyte subpopulations in patients with common variable immunodeficiency (CVID).

Materials and methods

During

SUBMITTER: Kostinova AM 

PROVIDER: S-EPMC11360582 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature