Cross-Omics Analyses Reveal the Effects of Ambient PM_2.5 Exposure on Hepatic Metabolism in Female Mice.

ABSTRACT: Ambient particulate matter (PM_2.5) is a potential risk factor for metabolic damage to the liver. Epidemiological studies suggest that elevated PM_2.5 concentrations cause changes in hepatic metabolism, but there is a lack of laboratory evidence. Here, we aimed to evaluate the effects of PM_2.5 exposure on liver metabolism in C57BL/6j female mice (10 months old) and to explore the mechanisms underlying metabolic alterations and differential gene expressions by combining metabolomics and transcriptomics analyses. The metabolomics results showed that PM_2.5 exposure notably affected the metabolism of amino acids and organic acids and caused hepatic lipid and bile acid accumulation. The transcriptomic analyses revealed that PM_2.5 exposure led

SUBMITTER: Yan R 

PROVIDER: S-EPMC11360593 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature