Prognostic Utility of the Flow Cytometry and Clonality Analysis Results for Feline Lymphomas.

ABSTRACT: Feline lymphoma, a prevalent cancer in cats, exhibits varied prognoses influenced by anatomical site and cellular characteristics. In this study, we investigated the utility of flow cytometry and clonality analysis via PCR for antigen receptor rearrangement (PARR) with respect to characterizing the disease and predicting prognosis. For this purpose, we received fine needle aspirates and/or blood from 438 feline patients, which were subjected to flow cytometry analysis and PARR. We used a subset of the results from patients with confirmed B- or T-cell lymphomas for comparison to cytological or histological evaluation (n = 53). Using them as a training set, we identified the optimal set of flow cytometry parameters, namely forward scatter thresholds, for cell size categorization by correlati

SUBMITTER: Kapoor S 

PROVIDER: S-EPMC11360694 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature