Limitations and Modifications of Skin Sensitization NAMs for Testing Inorganic Nanomaterials.

ABSTRACT: Since 2020, the REACh regulation requires toxicological data on nanoforms of materials, including the assessment of their skin-sensitizing properties. Small molecules' skin sensitization potential can be assessed by new approach methodologies (NAMs) addressing three key events (KE: protein interaction, activation of dendritic cells, and activation of keratinocytes) combined in a defined approach (DA) described in the OECD guideline 497. In the present study, the applicability of three NAMs (DPRA, LuSens, and h-CLAT) to nine materials (eight inorganic nanomaterials (NM) consisting of CeO₂, BaSO₄, TiO₂ or SiO₂, and quartz) was evaluated. The NAMs were technically applicable to NM using a specific sample preparation (NANOGENOTOX dispersion protocol)

SUBMITTER: Wareing B 

PROVIDER: S-EPMC11360696 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature