A Method for the Colorimetric Quantification of Sodium Lauryl Sulphate in Tablets: A Proof of Concept.

ABSTRACT: The deformulation stage of original drug products, which includes the quantification of critical excipients, is crucial for the successful development of generic drug products of solid dosage form. Sodium lauryl sulphate (SLS) belongs to the group of critical excipients due to its influence on the bioavailability of drugs, such as metformin. The purpose of this work is to carry out a feasibility study in order to develop a simple, economical, and robust analytical method for the quantification of SLS in metformin-containing tablets after their dissolution in water. Firstly, SLS is extracted with chloroform in acidic conditions, followed by the addition of methylene blue (MB) in order to form a SLS-MB ion pair, which is then measured photometrically at a wavelength of 651 nm. Additionally,

SUBMITTER: Paulausks A 

PROVIDER: S-EPMC11360801 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature