Independent concentration extraction as a novel green approach resolving overlapped UV-Vis binary spectra and HPTLC-densitometric methods for concurrent determination of levocloperastine and chlorpheniramine.

ABSTRACT:

Background

The proposed research study introduces independent concentration extraction (ICE) as a novel UV-Vis spectrophotometric approach. The approach can be used for extracting the concentration of two analytes with severely overlapped spectra from their binary mixtures. ICE is based on spectral extraction platform involving simple smart successive methods that can directly extract the original zero order spectra of the analytes at their characteristic (λ_max). Chlorpheniramine maleate (CPM) and Levocloperastine fendizoate (LCF) are two commonly co-formulated drugs in cough preparations. The combined mixture was used to confirm the validity of the developed ICE tool. Another less green HPTLC was developed for the first time to separate both drugs and help also in confi

SUBMITTER: Mohamed EH 

PROVIDER: S-EPMC11360872 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature