Interfering with aggregated α-synuclein in advanced melanoma leads to a major upregulation of MHC class II proteins.

ABSTRACT: Melanoma is the most serious and deadly form of skin cancer and with progression to advanced melanoma, the intrinsically disordered protein α-synuclein is upregulated to high levels. While toxic to dopaminergic neurons in Parkinson's disease, α-synuclein is highly beneficial for primary and metastatic melanoma cells. To gain detailed insights into this exact opposite role of α-synuclein in advanced melanoma, we performed proteomic studies of high-level α-synuclein-expressing human melanoma cell lines that were treated with the diphenyl-pyrazole small-molecule compound anle138b, which binds to and interferes with the oligomeric structure of α-synuclein. We also performed proteomic and transcriptomic studies of human melanoma xenografts that were treated systemically with the anle138b compou

SUBMITTER: Fokken C 

PROVIDER: S-EPMC11361348 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature