Endothelial Dysfunction in Youth-Onset Type 2 Diabetes: A Clinical Translational Study.

ABSTRACT:

Background

Youth-onset type 2 diabetes (Y-T2D) is associated with increased risk for coronary atherosclerotic disease, but the timing of the earliest pathological features and evidence of cardiac endothelial dysfunction have not been evaluated in this population. Endothelial function magnetic resonance imaging may detect early and direct endothelial dysfunction in the absence of classical risk factors (severe hyperglycemia, hypertension, and hyperlipidemia). Using endothelial function magnetic resonance imaging, we evaluated peripheral and coronary artery structure and endothelial function in young adults with Y-T2D diagnosed ≤5 years compared with age-matched healthy peers. We isolated and characterized plasma-derived small extracellular vesicles and evaluated their effects on inf

SUBMITTER: Abd-Elmoniem KZ 

PROVIDER: S-EPMC11361354 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature