Intramyocardial Sprouting Tip Cells Specify Coronary Arterialization.

ABSTRACT:

Background

The elaborate patterning of coronary arteries critically supports the high metabolic activity of the beating heart. How coronary endothelial cells coordinate hierarchical vascular remodeling and achieve arteriovenous specification remains largely unknown. Understanding the molecular and cellular cues that pattern coronary arteries is crucial to develop innovative therapeutic strategies that restore functional perfusion within the ischemic heart.

Methods

Single-cell transcriptomics and histological validation were used to delineate heterogeneous transcriptional states of the developing and mature coronary endothelium with a focus on sprouting endothelium and arterial cell specification. Genetic lineage tracing and high-resolution 3-dimensional imaging were used to

SUBMITTER: Cano E 

PROVIDER: S-EPMC11361357 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature