Loss of Y Chromosome and Cardiovascular Events in Chronic Kidney Disease.

ABSTRACT:

Background

Chronic kidney disease represents one of the strongest risk factors for cardiovascular diseases, and particularly for heart failure. Despite improved pharmaceutical treatments, mortality remains high. Recently, experimental studies demonstrated that mosaic loss of Y chromosome (LOY) associates with cardiac fibrosis in male mice. Since diffuse cardiac fibrosis is the common denominator for progression of all forms of heart failure, we determined the association of LOY on mortality and cardiovascular disease outcomes in patients with chronic kidney disease.

Methods

LOY was quantified in men with stable chronic kidney disease (CARE for HOMe study, n=279) and dialysis patients (4D study, n=544). The association between LOY and mortality, combined cardiovascular and he

SUBMITTER: Weyrich M 

PROVIDER: S-EPMC11361358 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature