The impact of biologic agents on cardiovascular risk factors in patients with rheumatoid arthritis: A meta analysis.

ABSTRACT:

Objective

The purpose of the study is to evaluate the effects of biologic therapy on cardiovascular risk factors in rheumatoid arthritis patients to determine its clinical efficacy.

Methods

Relevant literature was systematically searched in PubMed, Embase, and Cochrane Library databases. Meta-analysis was conducted using standardized mean differences (SMDs) and 95% confidence intervals (CIs) to evaluate cardiovascular risk factors and atherosclerosis. Heterogeneity, sensitivity analysis, and publication bias were assessed. Statistical significance was set at P<0.05.

Results

The meta-analysis revealed that biologic treatment in RA patients was associated with decreased high-density lipoprotein cholesterol (HDL-C) levels compared to controls (MD: -0.10, 95% CI: [-0.14,

SUBMITTER: Jia X 

PROVIDER: S-EPMC11361434 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature