Adverse Events in Patients Receiving Placebo in Phase III Trials of Biologics for Psoriasis: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Patients and practitioners often consider the risk of side effects when starting a treatment for psoriasis and often consult reported adverse events (AE) in studies. However, most of these AEs are unrelated to treatment and patients consider what is the risk of an event should you not start a treatment. This is what would be observed in the placebo-arm of clinical trials.

Objective

To investigate the proportion of patients experiencing AEs during treatment with placebo in clinical trials.

Methods

We conducted a systematic literature search using PubMed, Embase and Web of Science databases for phase 3 randomized clinical trials that registered adverse events of using placebo vs biological agents for psoriasis. The search term was "Psoriasis AND (Phase III

SUBMITTER: Ajenthen GD 

PROVIDER: S-EPMC11361480 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature