Mechanical and thermal thresholds before and after application of a conditioning stimulus in healthy Gottingen Minipigs.

ABSTRACT: Minipigs are widely used in biomedical research for translational studies. However, information about pain elicited by experimental procedures is lacking. Non-invasive methods as quantitative sensory testing and conditioned pain modulation are particularly attractive. Our overarching aim was to explore and refine these methods for assessing post-operative pain in minipigs after myocardial infarction. As first step, we aimed at defining mechanical and thermal thresholds in healthy adults Göttingen Minipigs, evaluating their reliability, and testing their modifications after the application of a conditioning stimulus. Thresholds were assessed at different body sites before and after a painful conditioning stimulus (CS) (cuffed tourniquet) and sham CS (uncuffed tourniquet) in eleven animals.

SUBMITTER: Petrucci M 

PROVIDER: S-EPMC11361583 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature