Epithelial IFNγ signalling and compartmentalized antigen presentation orchestrate gut immunity.

ABSTRACT: All nucleated cells express major histocompatibility complex I and interferon-γ (IFNγ) receptor¹, but an epithelial cell-specific function of IFNγ signalling or antigen presentation by means of major histocompatibility complex I has not been explored. We show here that on sensing IFNγ, colonic epithelial cells productively present pathogen and self-derived antigens to cognate intra-epithelial T cells, which are critically located at the epithelial barrier. Antigen presentation by the epithelial cells confers extracellular ATPase expression in cognate intra-epithelial T cells, which limits the accumulation of extracellular adenosine triphosphate and consequent activation of the NLRP3 inflammasome in tissue macrophages. By contrast, antigen presentation by the tissue macrophages a

SUBMITTER: Malik A 

PROVIDER: S-EPMC11361632 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature