Damage-induced basal epithelial cell migration modulates the spatial organization of redox signaling and sensory neuron regeneration.

ABSTRACT: Epithelial damage leads to early reactive oxygen species (ROS) signaling, which regulates sensory neuron regeneration and tissue repair. How the initial type of tissue injury influences early damage signaling and regenerative growth of sensory axons remains unclear. Previously we reported that thermal injury triggers distinct early tissue responses in larval zebrafish. Here, we found that thermal but not mechanical injury impairs sensory axon regeneration and function. Real-time imaging revealed an immediate tissue response to thermal injury characterized by the rapid Arp2/3-dependent migration of keratinocytes, which was associated with tissue scale ROS production and sustained sensory axon damage. Isotonic treatment was sufficient to limit keratinocyte movement, spatially restrict ROS pr

SUBMITTER: Fister AM 

PROVIDER: S-EPMC11361710 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature