Decellularized aortic homografts versus mechanical composite grafts for aortic root replacement.

ABSTRACT:

Objectives

Mechanical composite valve grafts (MCVGs) are the first-line therapy for aortic root replacement in young adults. Decellularized aortic homografts (DAH) present a promising novel alternative due to their lower thrombogenicity. We aimed to compare both treatment options regarding survival and valve-related adverse events.

Methods

This study was designed as a single-centre retrospective cohort study including patients who underwent root replacement with MCVG or DAH between 2000 and 2022. Urgent or emergent procedures were excluded.

Results

The study cohort included 289 patients (MCVG n = 216, DAH n = 73) with a mean age of 48.5 ± 12 years (MCVG 49 ± 12 years vs DAH 47 ± 11 years; P = 0.23) and a median EuroScore II of 1.7% (1.2, 2.6). The 30-day mortality was

SUBMITTER: Andreeva A 

PROVIDER: S-EPMC11361793 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature