Mediating effects of BMI on the association between DNA methylation regions and 24-h blood pressure in African Americans.

ABSTRACT:

Background

DNA methylation is an important epigenetic mechanism that may influence blood pressure (BP) regulation and hypertension risk. Obesity, a major lifestyle factor associated with hypertension, may interact with DNA methylation to affect BP. However, the indirect effect of DNA methylation on 24-h BP measurements mediated by obesity-related phenotypes such as BMI has not been investigated.

Methods

Causal mediation analysis was applied to examine the mediating role of BMI in the relation between DNA methylation and 24-h BP phenotypes, including SBP, DBP and mean arterial blood pressure (MAP), in 281 African American participants.

Results

Analysis of 38 215 DNA methylation regions, derived from 1 549 368 CpG sites across the genome, identified up to 138 methylatio

SUBMITTER: Pan X 

PROVIDER: S-EPMC11361834 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature