Cytoplasmatic Localization of Six1 in Male Testis and Spermatogonial Stem Cells.

ABSTRACT: Sine oculis homeobox 1 (Six1) is an important factor for embryonic development and carcinoma malignancy. However, the localization of Six1 varies due to protein size and cell types in different organs. In this study, we focus on the expression and localization of Six1 in male reproductive organ via bioinformatics analysis and immunofluorescent detection. The potential interacted proteins with Six1 were also predicted by protein-protein interactions (PPIs) and Enrichr analysis. Bioinformatic data from The Cancer Genome Atlas and Genotype-Tissue Expression project databases showed that SIX1 was highly expressed in normal human testis, but low expressed in the testicular germ cell tumor sample. Human Protein Atlas examination verified that SIX1 level was higher in normal than that in c

SUBMITTER: Qin M 

PROVIDER: S-EPMC11361848 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature