Ovarian carcinosarcomas: p53 status defines two distinct patterns of oncogenesis and outcomes.

ABSTRACT:

Objectives

Ovarian carcinosarcoma (OCS) is a rare and lethal type of ovarian cancer. Despite its incredibly poor prognosis, it has received little research attention. In this study, we aim to evaluate the molecular features of OCS and elucidate their clinical significance.

Study methods

We examined 30 OCS by immunohistochemistry (IHC) and targeted panel sequencing collected from a single institution (2003-2013) as the initial molecularly characterized cohort (Cohort A). From November 2016 to April 2023, we collected an additional 67 OCS cases from three institutions across British Columbia and Alberta as the contemporary cohort (Cohort B) for clinical correlation. The Kaplan-Meier method was used to estimate overall and progression-free survival, and differences in survival

SUBMITTER: Dhillon G 

PROVIDER: S-EPMC11361923 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature