Causal role of immune cells in bipolar disorder: a Mendelian randomization study.

ABSTRACT:

Background

The understanding of the immunological mechanisms underlying bipolar disorder (BD) has enhanced in recent years due to the extensive use of high-density genetic markers for genotyping and advancements in genome-wide association studies (GWAS). However, studies on the relationship between immune cells and the risk of BD remain limited, necessitating further investigation.

Methods

Bidirectional two-sample Mendelian Randomization (MR) analysis was employed to investigate the causal association between immune cell morphologies and bipolar disorder. Immune cell traits were collected from a research cohort in Sardinia, whereas the GWAS summary statistics for BD were obtained from the Psychiatric Genomics Consortium. Sensitivity analyses were conducted, and the combinati

SUBMITTER: Wang M 

PROVIDER: S-EPMC11362081 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature