Surfacing of Latent Time Memories Supports the Representational Basis of Timing Behavior in Mice.

ABSTRACT: Animals can adapt their reward expectancy to changes in delays to reward availability. When temporal relations are altered, associative models of interval timing predict that the original time memory is lost due to the updating of the underlying associative weights, whereas the representational models render the preservation of the original time memory (as previously demonstrated in the extinction of conditioned fear). The current study presents the critical test of these theoretical accounts by training mice with two different intervals in a consecutive fashion (short → long or long → short) and then testing timing behaviors during extinction where neither temporal relation is in effect. Mice that were trained with the long interval first clustered their anticipatory responses around the

SUBMITTER: Oztel T 

PROVIDER: S-EPMC11362479 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature