An atlas of the human liver diurnal transcriptome and its perturbation by hepatitis C virus infection.

ABSTRACT: Chronic liver disease and cancer are global health challenges. The role of the circadian clock as a regulator of liver physiology and disease is well established in rodents, however, the identity and epigenetic regulation of rhythmically expressed genes in human disease is less well studied. Here we unravel the rhythmic transcriptome and epigenome of human hepatocytes using male human liver chimeric mice. We identify a large number of rhythmically expressed protein coding genes in human hepatocytes of male chimeric mice, which includes key transcription factors, chromatin modifiers, and critical enzymes. We show that hepatitis C virus (HCV) infection, a major cause of liver disease and cancer, perturbs the transcriptome by altering the rhythmicity of the expression of more than 1000 genes,

SUBMITTER: Mukherji A 

PROVIDER: S-EPMC11362569 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature