XENTURION is a population-level multidimensional resource of xenografts and tumoroids from metastatic colorectal cancer patients.

ABSTRACT: The breadth and depth at which cancer models are interrogated contribute to the successful clinical translation of drug discovery efforts. In colorectal cancer (CRC), model availability is limited by a dearth of large-scale collections of patient-derived xenografts (PDXs) and paired tumoroids from metastatic disease, where experimental therapies are typically tested. Here we introduce XENTURION, an open-science resource offering a platform of 128 PDX models from patients with metastatic CRC, along with matched PDX-derived tumoroids. Multidimensional omics analyses indicate that tumoroids retain extensive molecular fidelity with parental PDXs. A tumoroid-based trial with the anti-EGFR antibody cetuximab reveals variable sensitivities that are consistent with clinical response biomarkers, mi

SUBMITTER: Leto SM 

PROVIDER: S-EPMC11362617 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature