Alpha-melanocyte-stimulating hormone contributes to an anti-inflammatory response to lipopolysaccharide.

ABSTRACT:

Objective

During infection, metabolism and immunity react dynamically to promote survival through mechanisms that remain unclear. Pro-opiomelanocortin (POMC) cleavage products are produced and released in the brain and in the pituitary gland. One POMC cleavage product, alpha-melanocyte-stimulating hormone (α-MSH), is known to regulate food intake and energy expenditure and has anti-inflammatory effects. However, it is not known whether α-MSH is required to regulate physiological anti-inflammatory responses. We recently developed a novel mouse model with a targeted mutation in Pomc (Pomc^tm1/tm1 mice) to block production of all α-MSH forms which are required to regulate metabolism. To test whether endogenous α-MSH is required to regulate immune responses, we compared acute

SUBMITTER: Reynolds RP 

PROVIDER: S-EPMC11362619 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature