Shilajit mitigates chemotherapeutic drug-induced testicular toxicity: Study on testicular germ cell dynamics, steroidogenesis modulation, and Nrf-2/Keap-1 signaling.

ABSTRACT:

Background

Medications, including chemotherapeutic drugs, contribute to male infertility as external factors by inducing oxidative stress in testicular cells. Shilajit is a naturally occurring bioactive antioxidant used in Ayurvedic medicine to treat a variety of ailments.

Objective

This study examines the potential of Shilajit to counteract the negative effects of the chemotherapeutic drug cyclophosphamide (CPA) on testicular germ cell dynamics.

Material and methods

Male Parkes mice received single intraperitoneal CPA injection (200 mg/kg BW) on day one, followed by daily supplementation of Shilajit (100 and 200 mg/kg BW) for one spermatogenic cycle.

Results

CPA adversely affected testicular germ cell dynamics by inhibiting the conversion of spermatogonia-to-s

SUBMITTER: Rajpoot A 

PROVIDER: S-EPMC11362644 | biostudies-literature | 2024 Jul-Aug

REPOSITORIES: biostudies-literature