A central role of sulcal width in the associations of sleep duration and depression with cognition in mid to late life.

ABSTRACT:

Study objectives

Evidence suggests that poor sleep impacts cognition, brain health, and dementia risk but the nature of the association is poorly understood. This study examined how self-reported sleep duration, napping, and subjective depression symptoms are associated with the brain-cognition relationship in older adults, using sulcal width as a measure of relative brain health.

Methods

A canonical partial least squares analysis was used to obtain two composite variables that relate cognition and sulcal width in a cross-sectional study of 137 adults aged 46-72. We used a combination of ANCOVA and path analyses to test the associations of self-reported sleep duration, napping, and subjective depression symptoms with the brain-cognition relationship.

Results

We observ

SUBMITTER: Faucher C 

PROVIDER: S-EPMC11362672 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature