PPIC-labeled CAFs: Key players in neoadjuvant chemotherapy resistance for gastric cancer.

ABSTRACT:

Background

Gastric cancer (GC) is the fourth leading cause of cancer deaths, with advanced cases having a median survival of less than one year. Neoadjuvant chemotherapy (NCT) is vital but faces drug resistance issues, partly due to cancer-associated fibroblasts (CAFs). Yet, specific CAF subpopulations contributing to resistance are poorly understood.

Methods

Differentially expressed genes (DEGs) between chemosensitive and resistant GC patients were identified using GEO2R. Single-cell sequencing (scRNA-seq) identified CAF-related genes. Immunohistochemistry verified key genes in NCT-treated GC samples, analyzing their correlation with tumor regression grade (TRG) and clinicopathological characteristics.

Results

PPIC as a gene highly expressed in CAFs was closely assoc

SUBMITTER: Yin H 

PROVIDER: S-EPMC11362775 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature