Frequent Alzheimer's disease neuropathological change in patients with glioblastoma.

ABSTRACT:

Background

The incidence of brain cancer and neurodegenerative diseases is increasing with a demographic shift towards aging populations. Biological parallels have been observed between glioblastoma and Alzheimer's disease (AD), which converge on accelerated brain aging. Here, we aimed to map the cooccurrence of AD neuropathological change (ADNC) in the tumor-adjacent cortex of patients with glioblastoma.

Methods

Immunohistochemical screening of AD markers amyloid beta (Abeta), amyloid precursor protein (APP), and hyperphosphorylated tau (pTau) was conducted in 420 tumor samples of 205 patients. For each cortex area, we quantified ADNC, neurons, tumor cells, and microglia.

Results

Fifty-two percent of patients (N = 106/205) showed ADNC (Abeta and pTau, Abeta or

SUBMITTER: Greutter L 

PROVIDER: S-EPMC11362848 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature