A layout framework for genome-wide multiple sequence alignment graphs.

ABSTRACT: Sequence alignments are often used to analyze genomic data. However, such alignments are often only calculated and compared on small sequence intervals for analysis purposes. When comparing longer sequences, these are usually divided into shorter sequence intervals for better alignment results. This usually means that the order context of the original sequence is lost. To prevent this, it is possible to use a graph structure to represent the order of the original sequence on the alignment blocks. The visualization of these graph structures can provide insights into the structural variations of genomes in a semi-global context. In this paper, we propose a new graph drawing framework for representing gMSA data. We produce a hierarchical graph layout that supports the comparative analysis of

SUBMITTER: Schebera J 

PROVIDER: S-EPMC11362851 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature