Efficacy and safety of a mineral and vitamin treatment on symptoms of antenatal depression: 12-week fully blinded randomised placebo-controlled trial (NUTRIMUM).

ABSTRACT:

Background

Broad-spectrum micronutrients (minerals and vitamins) have shown benefit for treatment of depressive symptoms.

Aims

To determine whether additional micronutrients reduce symptoms of antenatal depression.

Method

Eighty-eight medication-free pregnant women at 12-24 weeks gestation, who scored ≥13 on the Edinburgh Postnatal Depression Scale (EPDS), were randomised 1:1 to micronutrients or active placebo (containing iodine and riboflavin), for 12 weeks. Micronutrient doses were generally between recommended dietary allowance and tolerable upper level. Primary outcomes (EPDS and Clinical Global Impression - Improvement Scale (CGI-I)) were analysed with constrained longitudinal data analysis.

Results

Seventeen (19%) women dropped out, with no group differe

SUBMITTER: Bradley HA 

PROVIDER: S-EPMC11363078 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature